Clinical Research

Advancing the Field of Eyecare, One Clinical Study at a Time.

Research at Cincinnati Eye Institute

Cincinnati Eye Institute is home to one of the largest and most prestigious private-sector clinical research departments in ophthalmology in the United States. The eye doctors and research staff at CEI have been conducting clinical research for more than 35 years and have participated in over 300 research studies. Our goal is to pave the way for tomorrow’s eye care and bring it to our patients today.

Cincinnati Eye Institute is always participating in numerous studies across various sub-specialties for adults. Most commonly our clinical research studies are for dry eyes, glaucoma, cataracts, macular degeneration, diabetes, and more. If you have questions about any of our current studies with open enrollment, please contact the Clinical Research department by calling 513-569-3688 or by completing the form below.

Current Clinical Studies

Glaucoma View

Ivantis (CP 18-001)

Glaucoma surgical device post market study of the Hydrus microstent with cataract surgery
The Hydrus Microstent New Enrollment Post-Approval Study: A Prospective, Non-randomized, Multicenter, Single Arm, Clinical Trial (CONFIRM)

  • Physician: Anup Khatana, MD
  • Location: 1945 CEI Drive
  • Coordinator: Kelye Conrad (513) 569-3462

Mati Therapeutics (TGLA-2021-01)

Punctal Plug drug study for the treatment of elevated intraocular pressure
A 90-Day, Open-Label, Multi-Site, Pilot Study Evaluating the Safety and Intraocular Lowering Effect of Delivering Travoprost using a Punctal Plug Delivery System (Evolute®) in Subjects with Elevated Intraocular Pressure

  • Physician: Anup Khatana, MD
  • Location: 1945 CEI Drive
  • Coordinator: Victoria Barker (513) 569-3178

Ivantis (CP 20-002)

Glaucoma surgical device study of the Hydrus microstent without cataract surgery
The Hydrus Microstent for IOP Reduction in Mild to Moderate Open-Angle Glaucoma (FRONTIER)

  • Physician: Anup Khatana, MD
  • Location: 1945 CEI Drive
  • Coordinator: Gina Nordwick, (513) 569-3121
  • Physician: Edward Meier, MD
  • Location: 6150 Radio Way, Mason, OH 45040
  • Coordinator: Tina Winward, (513) 770-4020 ext.3324

Laboratoires Thea (LT4032-302)

Topical eye drop study for elevated intraocular pressure
Efficacy and safety assessment of T4032 (unpreserved bimatoprost 0.01%) versus Lumigan® 0.01% in ocular hypertensive or glaucomatous patients.

  • Physician: Linda Greff, MD
  • Location: 1945 CEI Drive, Cincinnati, OH 45242
  • Coordinator: Gina Nordwick (513) 569-3121

Cataract Surgery & Intraocular Lens (IOL) Studies View

Alcon Research (ILR431b-P001)

Evaluation of postoperative inflammation reported with the ReStor IOLs
A Prospective, Multi-Center, Post Approval Study of the AcrySof® IQ ReSTOR® Toric IOLs to Report the Rate of Post-Surgical Intraocular Inflammation Reported within a 180-Day Post-Surgical Period.

  • Physician: Michael Snyder, MD
  • Location: 1945 CEI Drive, Cincinnati, OH 45242
  • Coordinator: Victoria Barker, (513) 569-3178

AimMax (CPN-302)

Topical eye drop for pain and inflammation after cataract surgery
A Multicenter, Randomized, Double-Masked, Placebo-Controlled, Parallel-Group Study to Evaluate the Efficacy and Safety of APP13007 for the Treatment of Inflammation and Pain after Cataract Surgery, Including a Corneal Endothelial Cell Sub-Study

  • Physician: Michael Nordlund, MD
  • Location: 1945 CEI Drive, Cincinnati, OH 45242
  • Coordinator: Kelye Conrad, (513) 569-3462

Cornea Studies View

Trefoil Therapeutics (TTHX-901)

Intracameral injection for certain corneal dystrophies
A Phase 2 Clinical Trial to Assess the Safety and Observe the Potential Benefit of TTHX1114 Delivered via Intracameral (IC) Injection

  • Physician: Michael Snyder, MD
  • Location: 1945 CEI Drive, Cincinnati, OH 45242
  • Coordinator: Kelye Conrad (513) 569-3462

NYU Langone Health (16-00463)

Oral medication for Herpes Zoster Eye Disease
Phase 4, Long-term Suppressive Valacyclovir Treatment for Herpes Zoster Ophthalmicus

  • Physician: Kavitha Sivaraman, MD
  • Location: 1945 CEI Drive, Cincinnati, OH 45242
  • Coordinator: Kelye Conrad (513) 569-3462

Dry Eye Disease View

Allysta (ALY688-301)

Topical eye drop for Dry Eye Disease
A Phase 2b/3, Randomized, Double-Masked, Vehicle-Controlled Study Evaluating the Safety and Efficacy of Two Concentrations (0.4% and 1%) of ALY688 Ophthalmic Solution in Subjects with Dry Eye Disease (OASIS-1)

  • Physician: Karen Klugo, MD
  • Location: 5240 East Galbraith Road, Ste. B, Cincinnati, OH 45236
  • Coordinator: Misty Bruser, (513) 745-9787 ext. 3517
  • Physician: Robert Benza, MD
  • Location: 10615 Montgomery Rd., Ste. 202, Cincinnati, OH 45242
  • Coordinator: Candace Hayes, (513) 561-5655

Aramis Bio (A197-CS-201)

Topical eye drop for Dry Eye Disease
A phase 2, multicenter, double-masked, randomized, vehicle-controlled clinical trial evaluating the safety, tolerability, and efficacy of A197 in subjects with dry eye disease.

  • Physician: Edward Meier, MD
  • Location: 6150 Radio Way, Mason, OH 45040
  • Coordinator: Tina Winward, (513) 770-4020 ext.3324

Retina View

RegenxBio-Ascent (RGX-314-2101)

Gene Therapy surgical trial for Wet AMD
A Randomized, partially Masked, Controlled, Phase 3 Clinical Study to Evaluate the Efficacy and Safety of RGX-314 Gene Therapy in Participants with AMD.

  • Physician: Robert Sisk, MD
  • Coordinator: Gideon Gyebi, (513) 569-3331
  • Location: 1945 CEI Drive, Cincinnati, OH 45242

Gyroscope Therapeutics, Inc. (EXPLORE GT005-02)

Gene Therapy surgical trial for dry AMD
A Phase 2, Outcomes Assessor-Masked, Multicentre, Randomized Study to Evaluate the Safety and Efficacy of Two Doses of GT005 Administered as a Single Subretinal Injection in Subjects with Geographic Atrophy Secondary to Age-Related Macular Degeneration.

  • Physician: Christopher Riemann, MD
  • Coordinator: Gideon Gyebi, Phone 513-569-3331
  • Location: 1945 CEI Drive, Cincinnati, OH 45242

Gyroscope Therapeutics, Inc. (HORIZON GT005-03)

Gene Therapy surgical trial for dry AMD
A Phase II, Open-Label, Outcomes-Assessor Masked, Multicentre, Randomized, Controlled Study to Evaluate the Safety and Efficacy of Two Doses of GT005 Administered as a Single Subretinal Injection in Subjects with Geographic Atrophy Secondary to Dry Age-Related Macular Degeneration.

  • Physician: Christopher Riemann, MD
  • Coordinator: Gideon Gyebi, (513) 569-3331
  • Location: 1945 CEI Drive, Cincinnati, OH 45242

Gyroscope (Focus)

Gene Therapy surgical trial for dry AMD
An Open-Label First in Human Phase I/II Multicentre Study to Evaluate the Safety, Dose Response and Efficacy of GT005 Administered as a Single Subretinal Injection in Subjects with Macular Atrophy due to Age-Related Macular Degeneration.

  • Physician: Christopher Riemann, MD
  • Coordinator: Gideon Gyebi, (513) 569-3331
  • Location: 1945 CEI Drive, Cincinnati, OH 45242

Alimera-New (Day-01-20-005)

Intravitreal injection trial for diabetic macular edema
A Randomized, Masked, Controlled Study of Intravitreal ILUVIEN® Implant as Baseline Therapy in Patients with Early Diabetic Macular Edema (DME)

  • Physician: Christopher Riemann, MD
  • Coordinator: Harithasri Munukutla, (513) 569-3170
  • Location: 1945 CEI Drive, Cincinnati, OH 45242

BELVEDERE (ML43000)

Surgical trial for wet AMD using the port delivery system
A Phase IIIb/IV, Multicenter, Visual Assessor Masked Study of the Efficacy and Safety of the Port Delivery System with Ranibizumab in Patients with Neovascular Age-Related Macular Degeneration Previously Treated with Intravitreal Agents Other than Ranibizumab.

  • Physician: Daniel Miller, MD, PhD
  • Coordinator: Tejeswini Siva Sathya, (513) 569-3549
  • Location: 1945 CEI Drive, Cincinnati, OH 45242

Meet Our Clinical Research Team

Megan Kingdon

Megan Kingdon

Director of Clinical Research – EyeCare Partners

Kelye Conrad

Kelye Conrad

Clinical Research Manager, Ohio Region – EyeCare Partners

How Does Clinical Research Help Our Patients?

Thousands of patients with eye problems come to CEI each week to find leading-edge solutions to their eye care needs. In addition to patients from Ohio and Northern Kentucky, we see patients who travel from all over the nation to see our eye care experts. Our participation in clinical research allows us to offer patients the most advanced treatment options possible.

Staying on the Leading Edge of Eye Care Research

Our on-going commitment to physician-controlled eye care research enables us:

Contact Cincinnati Eye Institute

Do you have questions about ongoing clinical research at Cincinnati Eye Institute? Complete the form below to join our research registry, and a member of our team will contact you to discuss any questions you may have about active clinical trials.

Research Registry

The doctors at Cincinnati Eye Institute have either authored or reviewed the content on this site.

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